Visual Neuroscience

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Glaucoma November 2024

The Mechanisms of Neuroprotection by Topical Rho Kinase Inhibition in Experimental Mouse Glaucoma and Optic Neuropathy

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Sarah E. Quillen; Elizabeth C. Kimball; Kelsey A. Ritter-Gordy; Liya Du; Zhuochen Yuan; Mary E. Pease; Salaheddine Madhoun; Thao D. Nguyen; Thomas V. Johnson; Harry A. Quigley; Ian F. Pitha
TAGS: astrocytes, did not receive therapy or drug, eye, glaucoma, mice, neuroprotection, optic nerve disorders, phosphotransferases, proteins, intraocular pressure
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):43. https://doi.org/10.1167/iovs.65.13.43

Includes: Supplemental Content

Retinal Cell Biology November 2024

Blind But Alive – Congenital Loss of atoh7 Disrupts the Visual System of Adult Zebrafish

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Juliane Hammer; Paul Röppenack; Sarah Yousuf; Anja Machate; Marika Fischer; Stefan Hans; Michael Brand
TAGS: adult, zebrafish, phenotype, visual system, retina
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):42. https://doi.org/10.1167/iovs.65.13.42

Includes: Supplemental Content

Retina November 2024

Preservation of Murine Whole Eyes With Supplemented UW Cold Storage Solution: Anatomical Considerations

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Nicole A. Muench; Heather M. Schmitt; Cassandra L. Schlamp; An-Jey A. Su; Kia Washington; Robert W. Nickells
TAGS: cryopreservation, eye, mice
Trans. Vis. Sci. Tech.. 2024; 13(11):24. https://doi.org/10.1167/tvst.13.11.24

Includes: Supplemental Content

Biochemistry and Molecular Biology November 2024

Tapinarof, an Aryl Hydrocarbon Receptor Ligand, Mitigates Fibroblast Activation in Thyroid Eye Disease: Implications for Novel Therapy

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Charkira C. Patrick; Elisa Roztocil; Farha Husain; Steven E. Feldon; Collynn F. Woeller
TAGS: aryl hydrocarbon receptor, fibroblasts, graves' ophthalmopathy, ligands, signal transduction, tapinarof, platelet-derived growth factor, thymidylate synthase, proto-oncogene proteins c-akt
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):40. https://doi.org/10.1167/iovs.65.13.40

Includes: Supplemental Content

Visual Neuroscience November 2024

Overcoming Low mRNA Expression in White Matter: A Protocol for RNA Extraction From the Optic Nerve in Large Animals for Transcriptomic Analysis

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Zhonghao Yu; Yue Guan; Tian Xia; Xuanwen Li; Mingyue Liu; Yujia Huo; Zhuowei Wang; Zhirong Liu; Yuting Luo; Wentao Yan; Lanfang Sun; Wencan Wu; Baoguo Shen; Yikui Zhang
TAGS: optic nerve, rna, rna, messenger, white matter
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):25. https://doi.org/10.1167/iovs.65.13.25

Includes: Multimedia, Supplemental Content

Visual Neuroscience November 2024

The Electroretinogram I-Wave, a Component Originating in the Retinal OFF-Pathway, Associates With a Myopia Genetic Risk Polymorphism

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Zihe Xu; Jit Kai Tan; Krishnika Vetrivel; Xiaofan Jiang; Shaun M. Leo; Taha Bhatti; Ambreen Tariq; Andrew R. Webster; Anthony G. Robson; Christopher J. Hammond; Pirro G. Hysi; Omar A. Mahroo
TAGS: electroretinography, genetic risk, myopia, polymorphism
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):21. https://doi.org/10.1167/iovs.65.13.21

Includes: Supplemental Content

Retina November 2024

Factors Associated With Ocular Perfusion Measurements as Obtained With Laser Speckle Contrast Imaging

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Jacqueline Fröhlich; Marco Cattaneo; Philippe Valmaggia; Peter M. Maloca; Konstantin Gugleta; Leopold Schmetterer; Hendrik P.N. Scholl; Giacomo Calzetti
TAGS: laser speckle contrast imaging, optic disk, perfusion, vascular flow, eye, spectral domain-optical coherence tomography
Trans. Vis. Sci. Tech.. 2024; 13(11):8. https://doi.org/10.1167/tvst.13.11.8

Includes: Supplemental Content

Artificial Intelligence November 2024

SLOctolyzer: Fully Automatic Analysis Toolkit for Segmentation and Feature Extracting in Scanning Laser Ophthalmoscopy Images

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Jamie Burke; Samuel Gibbon; Justin Engelmann; Adam Threlfall; Ylenia Giarratano; Charlene Hamid; Stuart King; Ian J. C. MacCormick; Thomas J. MacGillivray
TAGS: optic disk, scanning laser ophthalmoscopy, fovea centralis, datasets, pixel
Trans. Vis. Sci. Tech.. 2024; 13(11):7. https://doi.org/10.1167/tvst.13.11.7

Includes: Supplemental Content

Retinal Cell Biology November 2024

Growth Hormone Neuroprotective Effects After an Optic Nerve Crush in the Male Rat

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David Epardo; Jerusa E. Balderas-Márquez; Cynthia A. Rodríguez-Arzate; Stéphanie C. Thébault; Martha Carranza; Maricela Luna; José Ávila-Mendoza; Denisse Calderón-Vallejo; J. Luis Quintanar; Carlos Arámburo; Carlos G. Martínez-Moreno
TAGS: axonal transport, electroretinography, neuroprotection, neuroprotective effect, optic nerve, proteins, retina, somatotropin, somatropin, wounds and injuries
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):17. https://doi.org/10.1167/iovs.65.13.17

Includes: Supplemental Content

Glaucoma November 2024

Downregulation of SARM1 Protects Retinal Ganglion Cell Axonal and Somal Degeneration Via JNK Activation in a Glaucomatous Model of Ocular Hypertension

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Xuejin Zhang; Ting Li; Rong Zhang; Junfeng Li; Kaidi Wang; Jihong Wu
TAGS: axon, down-regulation, glaucoma, ocular hypertension, optic nerve, retina, retinal ganglion cells, tissue degeneration, wounds and injuries, injections
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):7. https://doi.org/10.1167/iovs.65.13.7

Includes: Supplemental Content

Glaucoma November 2024

Progressive Optic Neuropathy in Hydrocephalic Ccdc13 Mutant Mice Caused by Impaired Axoplasmic Transport at the Optic Nerve Head

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Mingjuan Wu; Xinyi Zhao; Shanzhen Peng; Xiaoyu Zhang; Jiali Ru; Lijing Xie; Tao Wen; Yingchun Su; Shujuan Xu; Dianlei Guo; Jianmin Hu; Haotian Lin; Tiansen Li; Chunqiao Liu
TAGS: axonal transport, mice, optic disk, optic nerve, optic nerve disorders, axon, retina, hydrocephalus
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):5. https://doi.org/10.1167/iovs.65.13.5

Includes: Supplemental Content

Article November 2024

Individual differences reveal similarities in serial dependence effects across perceptual tasks, but not to oculomotor tasks

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Shuchen Guan; Alexander Goettker
TAGS: color, judgment, pupil, reflex, pupil light reflex
Journal of Vision. 2024; 24(12):2. https://doi.org/10.1167/jov.24.12.2

Retina November 2024

Retinal Function in Advanced Multiple Sclerosis

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James V. M. Hanson; Sara Single; Rahel B. Eberle; Veronika Kana; Benjamin V. Ineichen; Christina Gerth-Kahlert
TAGS: electroretinography, multiple sclerosis, eye
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):2. https://doi.org/10.1167/iovs.65.13.2

Includes: Supplemental Content

Glaucoma November 2024

Proposing a Methodology for Axon-Centric Analysis of IOP-Induced Mechanical Insult

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Manik Bansal; Bingrui Wang; Susannah Waxman; Fuqiang Zhong; Yi Hua; Yuankai Lu; Juan Reynaud; Brad Fortune; Ian A. Sigal
TAGS: axon, body tissue, intraocular pressure, optic disk, volume, reconstructive surgical procedures
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):1. https://doi.org/10.1167/iovs.65.13.1

Includes: Supplemental Content

Retina October 2024

Differential Localization and Functional Roles of mGluR6 Paralogs in Zebrafish Retina

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Marion Haug; Sara A. Haddad-Velioglu; Manuela Berger; Anja Enz; Jingjing Zang; Stephan C F. Neuhauss
TAGS: electroretinography, retina, zebrafish, proteins, retinal cone, antibodies, signal transduction
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):44. https://doi.org/10.1167/iovs.65.12.44

Includes: Supplemental Content

Retina October 2024

Roflumilast Attenuates Microglial Senescence and Retinal Inflammatory Neurodegeneration Post Retinal Ischemia Reperfusion Injury Through Inhibiting NLRP3 Inflammasome

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Chunlian Ou; Yiwei Lin; Jing Wen; Hongyang Zhang; Ying Xu; Naiyuan Zhang; Qiong Liu; Yingzi Wu; Jing Xu; Jing Wu
TAGS: aging, inflammasomes, nerve degeneration, nlr family, pyrin domain-containing 3 protein, older adult, reperfusion injury, retinal ischemia, roflumilast, wounds and injuries, microglia
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):38. https://doi.org/10.1167/iovs.65.12.38

Includes: Supplemental Content

Glaucoma October 2024

DAMPs Drive Fibroinflammatory Changes in the Glaucomatous ONH

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Emma K. Geiduschek; Emma K. Bricco; Colleen M. McDowell
TAGS: glaucoma, mice, optic disk, eye, retinal nerve fiber layer
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):13. https://doi.org/10.1167/iovs.65.12.13

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology October 2024

Rapid Amplification of Cerebrospinal Fluid Pressure as a Possible Mechanism for Optic Nerve Sheath Bleeding in Infants With Nonaccidental Head Injury

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Peter S. Stewart; Bindi S. Brook; Oliver E. Jensen; Tamsin A. Spelman; Robert J. Whittaker; Moussa A. Zouache
TAGS: amplification, cerebrospinal fluid pressure, craniocerebral trauma, hemorrhage, infant, optic nerve sheath, perturbations, sclera
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):9. https://doi.org/10.1167/iovs.65.12.9

Includes: Supplemental Content

Retina October 2024

Retinal Function in Young Adults Following Topical Application of Levodopa to the Eye

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Faran Sabeti; Kate Thomson; Ted Maddess; Cindy Karouta; Myra Leung; Nicola Anstice; Tina Jong; Regan Ashby
TAGS: eye, levodopa, retina, administration, topical, carbidopa, young adult, perimetry, placebos
Trans. Vis. Sci. Tech.. 2024; 13(10):12. https://doi.org/10.1167/tvst.13.10.12

Includes: Supplemental Content

Retina October 2024

Longitudinal Assessment of Retinal Microvasculature in Preclinical Alzheimer's Disease

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Katie R. Curro; Ruth M. A. van Nispen; Anouk den Braber; Elsmarieke M. van de Giessen; Jacoba A. van de Kreeke; H. Stevie Tan; Pieter-Jelle Visser; Femke H. Bouwman; Frank D. Verbraak
TAGS: alzheimer's disease, follow-up, optic disk, retinal vasculature, macula lutea
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):2. https://doi.org/10.1167/iovs.65.12.2

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The Mechanisms of Neuroprotection by Topical Rho Kinase Inhibition in Experimental Mouse Glaucoma and Optic Neuropathy

Blind But Alive – Congenital Loss of atoh7 Disrupts the Visual System of Adult Zebrafish

Preservation of Murine Whole Eyes With Supplemented UW Cold Storage Solution: Anatomical Considerations

Tapinarof, an Aryl Hydrocarbon Receptor Ligand, Mitigates Fibroblast Activation in Thyroid Eye Disease: Implications for Novel Therapy

Overcoming Low mRNA Expression in White Matter: A Protocol for RNA Extraction From the Optic Nerve in Large Animals for Transcriptomic Analysis

The Electroretinogram I-Wave, a Component Originating in the Retinal OFF-Pathway, Associates With a Myopia Genetic Risk Polymorphism

Factors Associated With Ocular Perfusion Measurements as Obtained With Laser Speckle Contrast Imaging

SLOctolyzer: Fully Automatic Analysis Toolkit for Segmentation and Feature Extracting in Scanning Laser Ophthalmoscopy Images

Growth Hormone Neuroprotective Effects After an Optic Nerve Crush in the Male Rat

Downregulation of SARM1 Protects Retinal Ganglion Cell Axonal and Somal Degeneration Via JNK Activation in a Glaucomatous Model of Ocular Hypertension

Progressive Optic Neuropathy in Hydrocephalic Ccdc13 Mutant Mice Caused by Impaired Axoplasmic Transport at the Optic Nerve Head

Individual differences reveal similarities in serial dependence effects across perceptual tasks, but not to oculomotor tasks

Retinal Function in Advanced Multiple Sclerosis

Proposing a Methodology for Axon-Centric Analysis of IOP-Induced Mechanical Insult

Differential Localization and Functional Roles of mGluR6 Paralogs in Zebrafish Retina

Roflumilast Attenuates Microglial Senescence and Retinal Inflammatory Neurodegeneration Post Retinal Ischemia Reperfusion Injury Through Inhibiting NLRP3 Inflammasome

DAMPs Drive Fibroinflammatory Changes in the Glaucomatous ONH

Rapid Amplification of Cerebrospinal Fluid Pressure as a Possible Mechanism for Optic Nerve Sheath Bleeding in Infants With Nonaccidental Head Injury

Retinal Function in Young Adults Following Topical Application of Levodopa to the Eye

Longitudinal Assessment of Retinal Microvasculature in Preclinical Alzheimer's Disease

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