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Genetics August 2022

Consequences of a Rare Complement Factor H Variant for Age-Related Macular Degeneration in the Amish

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Andrea R. Waksmunski; Kristy Miskimen; Yeunjoo E. Song; Michelle Grunin; Renee Laux; Denise Fuzzell; Sarada Fuzzell; Larry D. Adams; Laura Caywood; Michael Prough; Dwight Stambolian; William K. Scott; Margaret A. Pericak-Vance; Jonathan L. Haines
TAGS: age-related macular degeneration, alleles, complement factor h, proteins, c-reactive protein, rna
Invest. Ophthalmol. Vis. Sci.. 2022; 63(9):8. doi: https://doi.org/10.1167/iovs.63.9.8

Includes: Supplemental Content

Retina August 2022

Branched Chain Amino Acids Promote ATP Production Via Translocation of Glucose Transporters

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Sachiko Iwai; Tomoko Hasegawa; Hanako Ohashi Ikeda; Akitaka Tsujikawa
TAGS: amino acids, branched-chain, glucose transporter, translocation (genetics), glucose uptake, hela cells, glucose
Invest. Ophthalmol. Vis. Sci.. 2022; 63(9):7. doi: https://doi.org/10.1167/iovs.63.9.7

Includes: Supplemental Content

Retina August 2022

Longitudinal Evaluation of Changes in Retinal Architecture Using Optical Coherence Tomography in Achromatopsia

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Magdalini Triantafylla; Eleni Papageorgiou; Mervyn G. Thomas; Rebecca McLean; Susanne Kohl; Viral Sheth; Zhanhan Tu; Frank A. Proudlock; Irene Gottlob
TAGS: achromatopsia, follow-up, optical coherence tomography, foveal hypoplasia, charcot-marie-tooth disease, orthodromic circus-movement tachycardia, child, genetics, molecular
Invest. Ophthalmol. Vis. Sci.. 2022; 63(9):6. doi: https://doi.org/10.1167/iovs.63.9.6

Includes: Supplemental Content

Retina August 2022

Phenotypic Expression of CFH Rare Variants in Age-Related Macular Degeneration Patients in the Coimbra Eye Study

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Cláudia Farinha; Patrícia Barreto; Rita Coimbra; Adela Iutis; Maria Luz Cachulo; José Cunha-Vaz; Yara T. E. Lechanteur; Carel B. Hoyng; Rufino Silva
TAGS: age-related macular degeneration, eye, phenotype, drusen, genes, genetics
Invest. Ophthalmol. Vis. Sci.. 2022; 63(9):5. doi: https://doi.org/10.1167/iovs.63.9.5

Includes: Supplemental Content

Retinal Cell Biology August 2022

Ciliary Neurotrophic Factor Derived From Astrocytes Protects Retinal Ganglion Cells Through PI3K/AKT, JAK/STAT, and MAPK/ERK Pathways

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Kwanghyun Lee; Jin-Ok Choi; Ahreum Hwang; Hyoung Won Bae; Chan Yun Kim
TAGS: 1-phosphatidylinositol 3-kinase, astrocytes, ciliary neurotrophic factor, mitogen-activated protein kinases, proto-oncogene proteins c-akt, phosphoinositide 3-kinase, stat family gene, statim, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2022; 63(9):4. doi: https://doi.org/10.1167/iovs.63.9.4

Includes: Supplemental Content

Retina August 2022

Noninvasive Ophthalmic Imaging Measures Retinal Degeneration and Vision Deficits in Ndufs4 −/− Mouse Model of Mitochondrial Complex I Deficiency

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Maria I. Avrutsky; Jacqueline M. Lawson; Jade E. Smart; Claire W. Chen; Carol M. Troy
TAGS: complex i deficiency, electroretinography, mice, mitochondria, ophthalmic imaging, pathology, retinal degeneration, vision, reflex
Trans. Vis. Sci. Tech.. 2022; 11(8):5. doi: https://doi.org/10.1167/tvst.11.8.5

Includes: Supplemental Content

Multidisciplinary Ophthalmic Imaging July 2022

Photoreceptor and Retinal Pigment Epithelium Relationships in Eyes With Vitelliform Macular Dystrophy Revealed by Multimodal Adaptive Optics Imaging

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Tao Liu; Nancy Aguilera; Andrew J. Bower; Joanne Li; Ehsan Ullah; Alfredo Dubra; Catherine Cukras; Brian P. Brooks; Brett G. Jeffrey; Robert B. Hufnagel; Laryssa A. Huryn; Wadih M. Zein; Johnny Tam
TAGS: diagnostic imaging, eye, retinal cone, vitelliform dystrophy, optics, photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2022; 63(8):27. doi: https://doi.org/10.1167/iovs.63.8.27

Includes: Supplemental Content

Clinical and Epidemiologic Research July 2022

Foveal Curvature and Its Associations in UK Biobank Participants

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Abraham Olvera-Barrios; Yuka Kihara; Yue Wu; Alasdair N. Warwick; Philipp L. Müller; Katie M. Williams; Alicja R. Rudnicka; Christopher G. Owen; Aaron Y. Lee; Catherine Egan; Adnan Tufail; on behalf of the UK Biobank Eyes and Vision Consortium
TAGS: biobanks, ethnic group, income, eye, astigmatism, fovea centralis
Invest. Ophthalmol. Vis. Sci.. 2022; 63(8):26. doi: https://doi.org/10.1167/iovs.63.8.26

Includes: Supplemental Content

Retina July 2022

EGF Receptor Signaling Modulates YAP Activation and Promotes Experimental Proliferative Vitreoretinopathy

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Wei Zhang; Jing Li
TAGS: epidermal growth factor receptors, signal transduction, vitreoretinopathy, proliferative
Invest. Ophthalmol. Vis. Sci.. 2022; 63(8):24. doi: https://doi.org/10.1167/iovs.63.8.24

Retina July 2022

LGALS3BP in Microglia Promotes Retinal Angiogenesis Through PI3K/AKT Pathway During Hypoxia

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Chenyang Zhao; Yusen Liu; Jiayu Meng; Xiaotang Wang; Xianyang Liu; Wanqian Li; Qian Zhou; Junjie Xiang; Na Li; Shengping Hou
TAGS: 1-phosphatidylinositol 3-kinase, akt signaling pathway, angiogenesis, hypoxia, microglia
Invest. Ophthalmol. Vis. Sci.. 2022; 63(8):25. doi: https://doi.org/10.1167/iovs.63.8.25

Review July 2022

Evidence Suggesting the Role of Gut Dysbiosis in Diabetic Retinopathy

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Pratima Singh Thakur; David Aggarwal; Brijesh Takkar; Sisinthy Shivaji; Taraprasad Das
TAGS: diabetic retinopathy, dysbiosis, intestinal bacteria, retina
Invest. Ophthalmol. Vis. Sci.. 2022; 63(8):21. doi: https://doi.org/10.1167/iovs.63.8.21

Retina July 2022

Quantitative Evaluations of Posterior Staphylomas in Highly Myopic Eyes by Ultra-Widefield Optical Coherence Tomography

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Noriko Nakao; Tae Igarashi-Yokoi; Hiroyuki Takahashi; Shiqi Xie; Kosei Shinohara; Kyoko Ohno-Matsui
TAGS: eye, optical coherence tomography, staphyloma, shape
Invest. Ophthalmol. Vis. Sci.. 2022; 63(8):20. doi: https://doi.org/10.1167/iovs.63.8.20

Includes: Supplemental Content

Retina July 2022

Delineating the Clinical Phenotype of Patients With the c.629C>G, p.Pro210Arg Mutation in Peripherin-2

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Shannon M. Conley; Cynthia K. McClard; Maggie L. Mwoyosvi; Niyaf Alkadhem; Bojana Radojevic; Martin Klein; David Birch; Ashley Ellis; Sonny W. Icks; Tejesh Guddanti; Lea D. Bennett
TAGS: mutation, phenotype, proteins, retina
Invest. Ophthalmol. Vis. Sci.. 2022; 63(8):19. doi: https://doi.org/10.1167/iovs.63.8.19

Includes: Supplemental Content

Visual Neuroscience July 2022

Deletion of Protein Phosphatase 2A Accelerates Retinal Degeneration in GRK1- and Arr1-Deficient Mice

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Alexander V. Kolesnikov; Jennings Luu; Hui Jin; Krzysztof Palczewski; Vladimir J. Kefalov
TAGS: mice, retinal degeneration, protein phosphatase, retina, rod photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2022; 63(8):18. doi: https://doi.org/10.1167/iovs.63.8.18

Retina July 2022

How Vision Is Impaired From Aging to Early and Intermediate Age-Related Macular Degeneration: Insights From ALSTAR2 Baseline

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Cynthia Owsley; Thomas A. Swain; Gerald McGwin, Jr.; Mark E. Clark; Deepayan Kar; Jason N. Crosson; Christine A. Curcio
TAGS: age-related macular degeneration, aging, eye, vision, digestive tract decontamination
Trans. Vis. Sci. Tech.. 2022; 11(7):17. doi: https://doi.org/10.1167/tvst.11.7.17

Includes: Supplemental Content

Article July 2022

Foveal crowding appears to be robust to normal aging and glaucoma unlike parafoveal and peripheral crowding

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Foroogh Shamsi; Rong Liu; MiYoung Kwon
TAGS: crowding, glaucoma, parafoveal region, aging, vision
Journal of Vision. 2022; 22(8):10. doi: https://doi.org/10.1167/jov.22.8.10

Artificial Intelligence July 2022

AutoMorph: Automated Retinal Vascular Morphology Quantification Via a Deep Learning Pipeline

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Yukun Zhou; Siegfried K. Wagner; Mark A. Chia; An Zhao; Peter Woodward-Court; Moucheng Xu; Robbert Struyven; Daniel C. Alexander; Pearse A. Keane
TAGS: deep learning, image quality, language morphology, morphology, datasets
Trans. Vis. Sci. Tech.. 2022; 11(7):12. doi: https://doi.org/10.1167/tvst.11.7.12

Includes: Supplemental Content

Artificial Intelligence July 2022

A Diabetic Retinopathy Classification Framework Based on Deep-Learning Analysis of OCT Angiography

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Pengxiao Zang; Tristan T. Hormel; Xiaogang Wang; Kotaro Tsuboi; David Huang; Thomas S. Hwang; Yali Jia
TAGS: angiogram, deep learning, diabetic retinopathy, eye, fundus photography, maps, cell adhesion molecules
Trans. Vis. Sci. Tech.. 2022; 11(7):10. doi: https://doi.org/10.1167/tvst.11.7.10

Includes: Supplemental Content

Retina July 2022

Efficacy of an Anti-Semaphorin 3A Neutralizing Antibody in a Male Experimental Retinal Vein Occlusion Mouse Model

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Shinsuke Nakamura; Anri Nishinaka; Yae Hidaka; Masamitsu Shimazawa; Leo Thomas; Remko A. Bakker; Hideaki Hara
TAGS: mice, neutralizing antibodies, semaphorin-3a, semaphorins, antibodies, retinal vein occlusion, neuropilin-1, tumor necrosis factors, retina, vascular flow
Invest. Ophthalmol. Vis. Sci.. 2022; 63(8):14. doi: https://doi.org/10.1167/iovs.63.8.14

Retina July 2022

The Relationship Between Fetal Growth and Retinal Nerve Fiber Layer Thickness in a Cohort of Young Adults

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Kathleen I. C. Dyer; Paul G. Sanfilippo; Seyhan Yazar; Jamie E. Craig; Alex W. Hewitt; John P. Newnham; David A. Mackey; Samantha S. Y. Lee
TAGS: cohort studies, fetal growth, retinal nerve fiber layer, young adult, pregnancy, birth weight, fetus
Trans. Vis. Sci. Tech.. 2022; 11(7):8. doi: https://doi.org/10.1167/tvst.11.7.8

Includes: Supplemental Content

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Consequences of a Rare Complement Factor H Variant for Age-Related Macular Degeneration in the Amish

Branched Chain Amino Acids Promote ATP Production Via Translocation of Glucose Transporters

Longitudinal Evaluation of Changes in Retinal Architecture Using Optical Coherence Tomography in Achromatopsia

Phenotypic Expression of CFH Rare Variants in Age-Related Macular Degeneration Patients in the Coimbra Eye Study

Ciliary Neurotrophic Factor Derived From Astrocytes Protects Retinal Ganglion Cells Through PI3K/AKT, JAK/STAT, and MAPK/ERK Pathways

Noninvasive Ophthalmic Imaging Measures Retinal Degeneration and Vision Deficits in Ndufs4 −/− Mouse Model of Mitochondrial Complex I Deficiency

Photoreceptor and Retinal Pigment Epithelium Relationships in Eyes With Vitelliform Macular Dystrophy Revealed by Multimodal Adaptive Optics Imaging

Foveal Curvature and Its Associations in UK Biobank Participants

EGF Receptor Signaling Modulates YAP Activation and Promotes Experimental Proliferative Vitreoretinopathy

LGALS3BP in Microglia Promotes Retinal Angiogenesis Through PI3K/AKT Pathway During Hypoxia

Evidence Suggesting the Role of Gut Dysbiosis in Diabetic Retinopathy

Quantitative Evaluations of Posterior Staphylomas in Highly Myopic Eyes by Ultra-Widefield Optical Coherence Tomography

Delineating the Clinical Phenotype of Patients With the c.629C>G, p.Pro210Arg Mutation in Peripherin-2

Deletion of Protein Phosphatase 2A Accelerates Retinal Degeneration in GRK1- and Arr1-Deficient Mice

How Vision Is Impaired From Aging to Early and Intermediate Age-Related Macular Degeneration: Insights From ALSTAR2 Baseline

Foveal crowding appears to be robust to normal aging and glaucoma unlike parafoveal and peripheral crowding

AutoMorph: Automated Retinal Vascular Morphology Quantification Via a Deep Learning Pipeline

A Diabetic Retinopathy Classification Framework Based on Deep-Learning Analysis of OCT Angiography

Efficacy of an Anti-Semaphorin 3A Neutralizing Antibody in a Male Experimental Retinal Vein Occlusion Mouse Model

The Relationship Between Fetal Growth and Retinal Nerve Fiber Layer Thickness in a Cohort of Young Adults

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