Biochemistry and Molecular Biology

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Retina April 2024

Role of Hsa_circ_0000880 in the Regulation of High Glucose-Induced Apoptosis of Retinal Microvascular Endothelial Cells

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Jiawei Wang; Nannan Yang; Wanna Li; Han Zhang; Jianqiao Li
TAGS: apoptosis, circular rna, endothelial cells, glucose, epiretinal membrane, regulation
Trans. Vis. Sci. Tech.. 2024; 13(4):12. https://doi.org/10.1167/tvst.13.4.12

Biochemistry and Molecular Biology April 2024

Exploring the Impact of Saccharin on Neovascular Age-Related Macular Degeneration: A Comprehensive Study in Patients and Mice

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Steffen E. Künzel; Inga-Marie Pompös; Leonie T. M. Flesch; Dominik P. Frentzel; Vitus A. Knecht; Silvia Winkler; Sergej Skosyrski; Anne Rübsam; Felix Dreher; Norbert Kociok; Moritz Schütte; Alexandre Dubrac; Bodo Lange; Marie-Laure Yaspo; Hans Lehrach; Olaf Strauß; Antonia M. Joussen; Oliver Zeitz
TAGS: choroidal neovascularization, mice, saccharin, exudative age-related macular degeneration, metabolites
Invest. Ophthalmol. Vis. Sci.. 2024; 65(4):5. https://doi.org/10.1167/iovs.65.4.5

Includes: Supplemental Content

Biochemistry and Molecular Biology April 2024

Identification of Novel FZD4 Mutations in Familial Exudative Vitreoretinopathy and Investigating the Pathogenic Mechanisms of FZD4 Mutations

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Erkuan Dai; Min Liu; Shujin Li; Xiang Zhang; Shiyuan Wang; Rulian Zhao; Yunqi He; Li Peng; Liting Lv; Haodong Xiao; Mu Yang; Zhenglin Yang; Peiquan Zhao
TAGS: familial exudative vitreoretinopathies, missense mutation, mutation, proteins, tissue membrane
Invest. Ophthalmol. Vis. Sci.. 2024; 65(4):1. https://doi.org/10.1167/iovs.65.4.1

Includes: Supplemental Content

Biochemistry and Molecular Biology March 2024

NLRP3 Inflammasome Priming in the Retina of Diabetic Mice Requires REDD1-Dependent Activation of GSK3β

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Christopher M. McCurry; Siddharth Sunilkumar; Sandeep M. Subrahmanian; Esma I. Yerlikaya; Allyson L. Toro; Ashley M. VanCleave; Shaunaci A. Stevens; Alistair J. Barber; Jeffery M. Sundstrom; Michael D. Dennis
TAGS: diabetes mellitus, mice, nlr family, pyrin domain-containing 3 protein, retina, inflammasomes, hyperglycemic agents
Invest. Ophthalmol. Vis. Sci.. 2024; 65(3):34. https://doi.org/10.1167/iovs.65.3.34

Includes: Supplemental Content

Anatomy and Pathology/Oncology March 2024

scRNA-Seq: First Atlas and Cellular Landscape of Lacrimal Sac: Implications in Primary Acquired Nasolacrimal Duct Obstruction Pathogenesis

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Wenyue Zhang; Huan Huang; Xueru Liu; Leilei Zhang; Lunhao Li; Yi Ding; Yichuan Xiao; Mohammad Javed Ali; Hao Sun; Caiwen Xiao
TAGS: epithelial cells, genes, lacrimal sac, nasolacrimal duct obstruction, pathogenesis, rna, small cytoplasmic, neutrophils, b-lymphocytes, inflammation, t-lymphocytes
Invest. Ophthalmol. Vis. Sci.. 2024; 65(3):38. https://doi.org/10.1167/iovs.65.3.38

Includes: Supplemental Content

Glaucoma March 2024

Reduced Aqueous Humor Outflow Pathway Arborization in Childhood Glaucoma Eyes

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Shikha Gupta; Xiaowei Zhang; Arnav Panigrahi; Shakha; Raymond Fang; Clemens A. Strohmaier; Hao F. Zhang; Robert N. Weinreb; Viney Gupta; Alex S. Huang
TAGS: aqueous humor, eye, glaucoma, congenital, angiogram, adult, surgical procedures, operative, cataract
Trans. Vis. Sci. Tech.. 2024; 13(3):23. https://doi.org/10.1167/tvst.13.3.23

Includes: Supplemental Content

Biochemistry and Molecular Biology March 2024

Investigating the Impact of Dimer Interface Mutations on Norrin's Secretion and Norrin/β-Catenin Pathway Activation

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Min Liu; Erkuan Dai; Mu Yang; Shujin Li; Lin Fan; Yining Liu; Haodong Xiao; Peiquan Zhao; Zhenglin Yang
TAGS: bodily secretions, dimers, mutation, proteins, gain of function mutation, western blotting, fluorescent antibody technique
Invest. Ophthalmol. Vis. Sci.. 2024; 65(3):31. https://doi.org/10.1167/iovs.65.3.31

Includes: Multimedia, Supplemental Content

Glaucoma March 2024

ANGPTL7 and Its Role in IOP and Glaucoma

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Suzette Farber-Katz Brown; Hien Nguyen; Philip Mzyk; Michael L. De Ieso; Andrea M. Unser; Ian Brown; Pujhitha Ramesh; Hira Afzaal; Feryan Ahmed; Karen Y. Torrejon; Alan Nhan; Dalton Markrush; Tom Daly; Ellie Knecht; William McConaughy; Sara Halmos; Zhiquan Lucy Liu; Rachel Rennard; Andrew Peterson; W. Daniel Stamer
TAGS: antibodies, eye, glaucoma, intraocular pressure, mice, aqueous humor, oryctolagus cuniculus
Invest. Ophthalmol. Vis. Sci.. 2024; 65(3):22. https://doi.org/10.1167/iovs.65.3.22

Includes: Supplemental Content

Retina March 2024

Tandem Mass Tag LC-MS/MS of Aqueous Humor From Individuals With Type 2 Diabetes Without Retinopathy Reveals Early Dysregulation of Synaptic Proteins

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Mira M. Sachdeva; Yoonjung Lee; Eda K. Unlu; Neslihan D. Koseoglu; Eumee Cha; Jiangxia Wang; Christina R. Prescott; Allen O. Eghrari; Chan Hyun Na
TAGS: diabetes mellitus, type 2, liquid chromatography-mass spectrometry, proteins, proteomics, retinal diseases, transluminal attenuation gradient, aqueous humor, diabetes mellitus
Invest. Ophthalmol. Vis. Sci.. 2024; 65(3):16. https://doi.org/10.1167/iovs.65.3.16

Includes: Supplemental Content

Biochemistry and Molecular Biology March 2024

Isolation and Characterization of Extracellular Vesicles Through Orthogonal Approaches for the Development of Intraocular EV Therapy

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Justin Leung; Dimitrios Pollalis; Gopa K. G. Nair; Jeffrey K. Bailey; Britney O. Pennington; Amir I. Khan; Kaitlin R. Kelly; Ashley K. Yeh; Kartik S. Sundaram; Dennis O. Clegg; Chen-Ching Peng; Liya Xu; Sun Young Lee
TAGS: extracellular vesicles, mass or substance concentration per volume, particle, patient isolation, proteins, social isolation, pan-hematopoietic expression protein, biophysics, recovery of function, microscopes, transmission electron
Invest. Ophthalmol. Vis. Sci.. 2024; 65(3):6. https://doi.org/10.1167/iovs.65.3.6

Includes: Supplemental Content

Cornea March 2024

Substrate Stiffness Modulates Stemness and Differentiation of Rabbit Corneal Endothelium Through the Paxillin–YAP Pathway

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Shuting Liu; Hua Chen; Huatao Xie; Xin Liu; Mingchang Zhang
TAGS: chronic exertional compartment syndrome, cornea, corneal endothelium, oryctolagus cuniculus, scirrhous adenocarcinoma
Invest. Ophthalmol. Vis. Sci.. 2024; 65(3):15. https://doi.org/10.1167/iovs.65.3.15

Includes: Supplemental Content

Cornea March 2024

NEAT1 Deficiency Promotes Corneal Epithelial Wound Healing by Activating cAMP Signaling Pathway

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Tian Sang; Yani Wang; Zhiqing Wang; Di Sun; Shengqian Dou; Yaoyao Yu; Xiaoyun Wang; Can Zhao; Qun Wang
TAGS: cornea, cyclic amp, epithelium, signal pathway, signal transduction pathways, wound healing, mice, inflammation
Invest. Ophthalmol. Vis. Sci.. 2024; 65(3):10. https://doi.org/10.1167/iovs.65.3.10

Includes: Supplemental Content

Biochemistry and Molecular Biology March 2024

Unraveling the Intraday Variations in the Tear Fluid Proteome

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Garrett Jones; Jeremy Altman; Saleh Ahmed; Tae Jin Lee; Wenbo Zhi; Shruti Sharma; Ashok Sharma
TAGS: proteins, proteome
Invest. Ophthalmol. Vis. Sci.. 2024; 65(3):2. https://doi.org/10.1167/iovs.65.3.2

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology March 2024

Alteration of Neurotrophic Factors and Innervation in Extraocular Muscles of Individuals With Concomitant Esotropia

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Jie Hao; Meixu Wang; Jiawen Liu; Mayinuer Yusufu; Kai Cao; Jing Fu
TAGS: esotropia, insulin-like growth factor i, muscle of orbit, nerve growth factors, nerve supply, fluorescent antibody technique
Invest. Ophthalmol. Vis. Sci.. 2024; 65(3):1. https://doi.org/10.1167/iovs.65.3.1

Glaucoma February 2024

Assessment of Causality Between Diet-Derived Antioxidants and Primary Open-Angle Glaucoma: A Mendelian Randomization Study

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Kun Xiong; Qi'ao Zhang; Huiyan Mao; Nathan Congdon; Yuanbo Liang
TAGS: antioxidants, diet, glaucoma, mendelian randomization analysis, open-angle glaucoma, instrumental variables, genetics
Trans. Vis. Sci. Tech.. 2024; 13(2):20. https://doi.org/10.1167/tvst.13.2.20

Includes: Supplemental Content

Biochemistry and Molecular Biology February 2024

Deficiency of Acetyltransferase nat10 in Zebrafish Causes Developmental Defects in the Visual Function

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Hou-Zhi Yang; Donghai Zhuo; Zongyu Huang; Gan Luo; Shuang Liang; Yonggang Fan; Ying Zhao; Xinxin Lv; Caizhen Qiu; Lingzhu Zhang; Yang Liu; Tianwei Sun; Xu Chen; Shan-Shan Li; Xin Jin
TAGS: zebrafish, congenital abnormality, vision, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2024; 65(2):31. https://doi.org/10.1167/iovs.65.2.31

Anatomy and Pathology/Oncology February 2024

Impact of Nintedanib and Anti-Angiogenic Agents on Uveal Melanoma Cell Behavior

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Vera E. Pawlik; Svenja R. Sonntag; Salvatore Grisanti; Aysegül Tura; Vinodh Kakkassery; Mahdy Ranjbar
TAGS: aflibercept, angiogenesis inhibitors, bevacizumab, intraocular melanoma, nintedanib, ranibizumab, vascular endothelial growth factor a, cell lines, mass or substance concentration per volume
Invest. Ophthalmol. Vis. Sci.. 2024; 65(2):30. https://doi.org/10.1167/iovs.65.2.30

Includes: Supplemental Content

Cornea & External Disease February 2024

Detection of TTR Amyloid in the Conjunctiva Using a Novel Fluorescent Ocular Tracer

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Julie Pilotte; Alex S. Huang; Sami Khoury; Xiaowei Zhang; Ali Tafreshi; Peter Vanderklish; Stella T. Sarraf; Jose S. Pulido; Tatyana Milman
TAGS: amyloid, body tissue, conjunctiva, eye
Trans. Vis. Sci. Tech.. 2024; 13(2):11. https://doi.org/10.1167/tvst.13.2.11

Retina February 2024

Histologic and Immunohistochemical Characterization of GA-Like Pathology in the Rat Subretinal Sodium Iodate Model

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Poonam Naik; Rhonda Grebe; Imran A. Bhutto; D. Scott McLeod; Malia M. Edwards
TAGS: atrophic condition of skin, atrophy, eye, immunohistochemistry, injections, iodates, pathology, sodium, tissue membrane, choroid
Trans. Vis. Sci. Tech.. 2024; 13(2):10. https://doi.org/10.1167/tvst.13.2.10

Retinal Cell Biology February 2024

5-Aza-2′-Deoxycytidine Ameliorates Choroidal Neovascularization by Inhibiting the Wnt/β-Catenin Signaling Pathway

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Xinyuan Wu; Xi Yang; Xiaochan Dai; Xiuping Chen; Minqian Shen; Jinhui Dai; Fei Yuan; Liyang Wang; Yuanzhi Yuan; Yifan Feng
TAGS: choroidal neovascularization, deoxycytidine, lasers, mice
Invest. Ophthalmol. Vis. Sci.. 2024; 65(2):23. https://doi.org/10.1167/iovs.65.2.23

Includes: Supplemental Content

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Role of Hsa_circ_0000880 in the Regulation of High Glucose-Induced Apoptosis of Retinal Microvascular Endothelial Cells

Exploring the Impact of Saccharin on Neovascular Age-Related Macular Degeneration: A Comprehensive Study in Patients and Mice

Identification of Novel FZD4 Mutations in Familial Exudative Vitreoretinopathy and Investigating the Pathogenic Mechanisms of FZD4 Mutations

NLRP3 Inflammasome Priming in the Retina of Diabetic Mice Requires REDD1-Dependent Activation of GSK3β

scRNA-Seq: First Atlas and Cellular Landscape of Lacrimal Sac: Implications in Primary Acquired Nasolacrimal Duct Obstruction Pathogenesis

Reduced Aqueous Humor Outflow Pathway Arborization in Childhood Glaucoma Eyes

Investigating the Impact of Dimer Interface Mutations on Norrin's Secretion and Norrin/β-Catenin Pathway Activation

ANGPTL7 and Its Role in IOP and Glaucoma

Tandem Mass Tag LC-MS/MS of Aqueous Humor From Individuals With Type 2 Diabetes Without Retinopathy Reveals Early Dysregulation of Synaptic Proteins

Isolation and Characterization of Extracellular Vesicles Through Orthogonal Approaches for the Development of Intraocular EV Therapy

Substrate Stiffness Modulates Stemness and Differentiation of Rabbit Corneal Endothelium Through the Paxillin–YAP Pathway

NEAT1 Deficiency Promotes Corneal Epithelial Wound Healing by Activating cAMP Signaling Pathway

Unraveling the Intraday Variations in the Tear Fluid Proteome

Alteration of Neurotrophic Factors and Innervation in Extraocular Muscles of Individuals With Concomitant Esotropia

Assessment of Causality Between Diet-Derived Antioxidants and Primary Open-Angle Glaucoma: A Mendelian Randomization Study

Deficiency of Acetyltransferase nat10 in Zebrafish Causes Developmental Defects in the Visual Function

Impact of Nintedanib and Anti-Angiogenic Agents on Uveal Melanoma Cell Behavior

Detection of TTR Amyloid in the Conjunctiva Using a Novel Fluorescent Ocular Tracer

Histologic and Immunohistochemical Characterization of GA-Like Pathology in the Rat Subretinal Sodium Iodate Model

5-Aza-2′-Deoxycytidine Ameliorates Choroidal Neovascularization by Inhibiting the Wnt/β-Catenin Signaling Pathway

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